STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1257227aa long hypothetical protein; Similar to owl:B64371 percent identity: 58.986 in 218aa. (227 aa)    
Predicted Functional Partners:
PH1102
480aa long hypothetical asparagine synthetase; Similar to PIR:C64439 percent identity: 45.304 in 190aa.
      0.910
PH0725
265aa long hypothetical diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.908
PH1907
178aa long hypothetical inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
      
 0.816
PH1347
308aa long hypothetical GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.772
PH1899
735aa long hypothetical elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation facto [...]
  
 
 0.758
PH0854
137aa long hypothetical protein; Similar to Swiss_Prot:P37552 percent identity: 55.738 in 123aa; owl:HPAE0006038 percent identity: 53.600 in 125aa; Swiss_Prot:P39330 percent identity: 56.098 in 127aa; Belongs to the RutC family.
      
 0.670
PHS034
65aa long hypothetical zinc finger protein; Similar to owl:nrl_1meyg percent identity:43.478 in 23aa. motif=zinc finger, C2H2 type, domain.
       0.620
PH1255
180aa long hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
       0.510
PH1256
292aa long hypothetical heat shock protein; Similar to PIR:H64509 percent identity: 59.921 in 255aa; Belongs to the peptidase M48B family.
       0.510
PH1105
342aa long hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).
  
   
 0.439
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.