STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1295425aa long hypothetical proton glutamate symport protein; Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (Ref.11). Has only very low glutamate transport activity. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (Ref.11). Na(+) binding enhances the affinity for aspartate. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. In contrast to mammalian homologs, tran [...] (425 aa)    
Predicted Functional Partners:
PH1686
570aa long hypothetical glutaminyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
     
 0.660
PH0781
526aa long hypothetical alanine transport protein; Similar to Swiss_Prot:P44917 percent identity: 42.202 in 517aa; owl:HPAE0006036 percent identity: 43.736 in 524aa; Swiss_Prot:P44555 percent identity: 38.095 in 311aa. motif=sodium:alanine symporter family signature.
  
  
 0.591
PH1044
491aa long hypothetical protein; Similar to owl:BSY140812 percent identity: 34.873 in 437aa; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
  
 0.506
PH1361
537aa long hypothetical proline permease; Similar to owl:BSU924662 percent identity: 35.581 in 436aa; owl:HPAE0005273 percent identity: 36.406 in 440aa; owl:D5045324 percent identity: 37.692 in 396aa. motif=prokaryotic membrane lipoprotein lipid attachment site; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
  
 0.506
PH1372
521aa long hypothetical sodium-dependent transporter; Similar to PIR:F64464 percent identity: 28.918 in 488aa.
 
  
 0.498
PH1721
273aa long hypothetical ribosomal protein S6 modification protein; Similar to PIR:D64377 percent identity:31.441 in 238aa.
     
 0.438
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.