STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1387307aa long hypothetical phosphoglycerate dehydrogenase; Similar to PIR:A64427 percent identity: 55.960 in 305aa; owl:S75016 percent identity: 43.709 in 304aa; owl:CEC31C91 percent identity: 41.391 in 304aa. motif=ATP/GTP-binding site motif A (P-loop); D-isomer specific 2-hydroxyacid dehydrogenases signatures. (307 aa)    
Predicted Functional Partners:
PH0520
333aa long hypothetical dehydrogenase; Similar to PIR:A64427 percent identity: 38.636 in 317aa; owl:BSZ9404317 percent identity: 36.122 in 268aa; Swiss_Prot:P37666 percent identity: 32.384 in 288aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
 
0.923
PH1722
323aa long hypothetical 3-isopropylmalate dehydrogenase; May play a dual role in glutamate and lysine biosynthesis in vivo. Uses isocitrate and homoisocitrate at near equal efficiency and preferentially uses NAD over NADP.
 
  
 0.922
PH0037
412aa long hypothetical phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
 0.911
PH1390
301aa long hypothetical thiamin biosynthesis protein; Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.
  
  
 0.831
PH1389
212aa long hypothetical protein; Belongs to the UPF0111 family.
       0.819
PH1308
386aa long hypothetical serine aminotransferase; Similar to PIR:G64419 percent identity: 34.637 in 362aa; PIR:JC2256 percent identity: 33.803 in 360aa; owl:S75916 percent identity: 34.551 in 364aa.
 
  
 0.716
PH1386
560aa long hypothetical protein; Similar to owl:S76831 percent identity: 36.270 in 542aa; Belongs to the glycosyl hydrolase 57 family.
   
  
 0.716
PH1885
210aa long hypothetical phosphoserine phosphatase; Similar to PIR:A64499 percent identity:32.673 in 206aa.
  
 
 0.687
PH1075
319aa long hypothetical homoserine dehydrogenase; Similar to PIR:A64500 percent identity: 34.967 in 329aa.
 
 
 0.681
PH1654
427aa long hypothetical serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.681
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.