STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1459310aa long hypothetical fructokinase; Similar to Swiss_Prot:P37829 percent identity: 34.118 in 261aa; owl:BVU37838 percent identity: 36.525 in 301aa; owl:LEU62329 percent identity: 37.500 in 270aa. motif=pfkB family of carbohydrate kinases signatures. (310 aa)    
Predicted Functional Partners:
PH0510
325aa long hypothetical protein.
  
 
 0.935
PH0243
601aa long hypothetical glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
  
 
 0.918
PH0759
390aa long hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
 0.916
PH0925
464aa long hypothetical mannose-1-phosphate guanylyl transferase; Similar to Swiss_Prot:P29956 percent identity:49.776 in 474aa; owl:YEU4685916 percent identity:45.721 in 470aa; PIR:E56146 percent identity:44.371 in 474aa; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.912
PH1956
192aa long hypothetical protein.
  
 
 0.909
PH1987
324aa long hypothetical O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
     
 0.719
PH1462
483aa long hypothetical protein.
 
   
 0.669
PH1474
267aa long hypothetical protein.
  
  
 0.656
PH1882
335aa long hypothetical glucose-fructose oxidoreductase; Similar to owl:ZMGFO percent identity:28.788 in 201aa; PIR:S70672 percent identity:29.317 in 258aa.
 
  
 0.614
PH1881
371aa long hypothetical protein; Similar to owl:BSY0947623 percent identity:28.399 in 344aa.
 
  
 0.606
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: high (82%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.