STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1724163aa long hypothetical 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa)    
Predicted Functional Partners:
PH1722
323aa long hypothetical 3-isopropylmalate dehydrogenase; May play a dual role in glutamate and lysine biosynthesis in vivo. Uses isocitrate and homoisocitrate at near equal efficiency and preferentially uses NAD over NADP.
 
 0.999
PH1726
380aa long hypothetical isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
PH1727
361aa long hypothetical 2-isopropylmalate synthase; Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
 
 
 0.999
PH1221
138aa long hypothetical protein.
  
  
 0.935
PH1720
330aa long hypothetical N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
     
 0.874
PH0834
571aa long hypothetical oxaloacetate decarboxylase alpha chain; Similar to PIR:F64453 percent identity: 56.150 in 571aa; owl:LPOADAGEN percent identity: 47.518 in 593aa; Swiss_Prot:Q03030 percent identity: 46.032 in 590aa. motif=biotin-requiring enzymes attachment site.
  
 
 0.845
PH1716
366aa long hypothetical acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
  
  
 0.838
PH1275
439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme]; Similar to owl:AF008220168 percent identity: 51.621 in 415aa; Swiss_Prot:P16468 percent identity: 55.795 in 384aa; owl:SBU35659 percent identity: 54.885 in 360aa. motif=malic enzymes signature.
  
 
 0.833
PH0570
478aa long hypothetical pyruvate kinase; Similar to PIR:A57418 percent identity:76.037 in 217aa; PIR:S76677 percent identity:42.128 in 484aa; Swiss_Prot:Q02499 percent identity:43.991 in 475aa. motif=eukaryotic thiol (cysteine) proteases active sites; Belongs to the pyruvate kinase family.
  
 
 0.831
PH1283
400aa long hypothetical methylmalonyl-CoA decarboxylase beta chain; Similar to PIR:E49094 percent identity: 67.007 in 294aa; Swiss_Prot:Q03031 percent identity: 63.907 in 308aa; Swiss_Prot:P13156 percent identity: 63.830 in 194aa.
     
 0.817
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.