STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1726380aa long hypothetical isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (380 aa)    
Predicted Functional Partners:
PH1722
323aa long hypothetical 3-isopropylmalate dehydrogenase; May play a dual role in glutamate and lysine biosynthesis in vivo. Uses isocitrate and homoisocitrate at near equal efficiency and preferentially uses NAD over NADP.
 0.999
PH1724
163aa long hypothetical 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 0.999
PH1727
361aa long hypothetical 2-isopropylmalate synthase; Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
 
 0.999
PH1221
138aa long hypothetical protein.
  
  
 0.945
PH0570
478aa long hypothetical pyruvate kinase; Similar to PIR:A57418 percent identity:76.037 in 217aa; PIR:S76677 percent identity:42.128 in 484aa; Swiss_Prot:Q02499 percent identity:43.991 in 475aa. motif=eukaryotic thiol (cysteine) proteases active sites; Belongs to the pyruvate kinase family.
    
 0.828
PH1275
439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme]; Similar to owl:AF008220168 percent identity: 51.621 in 415aa; Swiss_Prot:P16468 percent identity: 55.795 in 384aa; owl:SBU35659 percent identity: 54.885 in 360aa. motif=malic enzymes signature.
    
 0.817
PH1716
366aa long hypothetical acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
 
   
 0.816
PH0678
185aa long hypothetical ferredoxin oxidoreductase gamma subunit; Similar to owl:PFPORVOR5 percent identity: 90.270 in 185aa; PIR:F64333 percent identity: 65.698 in 179aa; owl:TMPMRFDNA2 percent identity: 44.000 in 177aa.
  
 
 0.815
PH1661
281aa long hypothetical ferredoxin oxidoreductase beta subunit; Similar to PIR:A64367 percent identity: 54.373 in 263aa; owl:HPAE0005725 percent identity: 44.697 in 265aa; PIR:S22397 percent identity: 43.011 in 186aa.
   
 
 0.812
PH1665
284aa long hypothetical ferredoxin oxidoreductase beta subunit; Similar to PIR:A64367 percent identity: 57.303 in 268aa; owl:HPAE0005725 percent identity: 45.643 in 242aa; PIR:JC4920 percent identity: 45.161 in 187aa.
   
 
 0.812
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: medium (72%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.