STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1792557aa long hypothetical CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (557 aa)    
Predicted Functional Partners:
PH1347
308aa long hypothetical GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.959
PH0698
160aa long hypothetical nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.955
PH1997
156aa long hypothetical protein; Catalyzes the deamination of dCTP to dUTP.
  
 
 0.939
PH1629
205aa long hypothetical 30S ribosomal protein S2; Similar to Swiss_Prot:P54109 percent identity: 66.667 in 192aa; owl:SS56KBFR54 percent identity: 57.071 in 198aa; Swiss_Prot:P29202 percent identity: 57.627 in 177aa. motif=ribosomal protein S2 signatures; Belongs to the universal ribosomal protein uS2 family.
  
 
 0.935
PH0021
611aa long hypothetical protein; motif=ATP/GTP-binding site motif A (P-loop).
     
 0.920
PH1478
629aa long hypothetical arginyl-tRNA synthetase; Similar to PIR:F64329 percent identity: 40.975 in 639aa; Swiss_Prot:P43832 percent identity: 40.000 in 192aa. motif=aminoacyl-transfer RNA synthetases class-I signature.
  
  
 0.916
PH1408
226aa long hypothetical protein; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.912
PH1999
342aa long hypothetical acidic ribosomal protein P0 (L10E); Forms the large subunit's ribosomal stalk, playing a central role in the interaction of the ribosome with elongation factors; the stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes, although the first site is the most stimulatory; Belongs to the universal ribosomal protein uL10 family.
   
 
 0.900
PH1634
142aa long hypothetical 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.896
PH1763
187aa long hypothetical 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
 
 0.891
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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