STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1998111aa long hypothetical 50S ribosomal protein L12; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes. (111 aa)    
Predicted Functional Partners:
PH0859
590aa long hypothetical transport protein; Similar to PIR:G64389 percent identity: 61.921 in 596aa; owl:S63672 percent identity: 48.048 in 594aa; PIR:S58091 percent identity: 50.000 in 599aa. motif=4Fe-4S ferredoxins, iron-sulfur binding region signature; ABC transporters family signature; ATP/.
  
   0.999
PH1999
342aa long hypothetical acidic ribosomal protein P0 (L10E); Forms the large subunit's ribosomal stalk, playing a central role in the interaction of the ribosome with elongation factors; the stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes, although the first site is the most stimulatory; Belongs to the universal ribosomal protein uL10 family.
 
 0.999
PH2000
219aa long hypothetical 50S ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
 
 0.998
PHS032
97aa long hypothetical 50S ribosomal protein L21; Similar to Swiss_Prot:P54013 percent identity: 67.368 in 95aa; Swiss_Prot:P12734 percent identity: 51.163 in 86aa; GENPEPT:F20014 percent identity: 37.500 in 72aa; Belongs to the eukaryotic ribosomal protein eL21 family.
   
 0.998
PHS043
99aa long hypothetical 50S ribosomal protein L30; Similar to Swiss_Prot:P29160 percent identity: 70.833 in 96aa; Swiss_Prot:P54061 percent identity: 50.505 in 99aa; Swiss_Prot:P11522 percent identity: 50.538 in 93aa. motif=ribosomal protein L30e signatures; Belongs to the eukaryotic ribosomal protein eL30 family.
   
 0.998
PH1756
155aa long hypothetical 50S ribosomal protein L30; Similar to Swiss_Prot:P54046 percent identity: 66.667 in 152aa; Swiss_Prot:P14035 percent identity: 54.000 in 152aa; GENPEPT:Y07778 percent identity: 43.709 in 153aa. motif=ribosomal protein L30 signature.
  
 0.998
PH1758
206aa long hypothetical 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
  
 0.998
PH0978
238aa long hypothetical 50S ribosomal protein L15; Similar to Swiss_Prot:P54060 percent identity: 70.103 in 194aa; Swiss_Prot:P49403 percent identity: 60.638 in 188aa; owl:ATFCA635 percent identity: 51.064 in 190aa. motif=ribosomal protein L15e signature; tubulin-beta mRNA autoregulation signal; Belongs to the eukaryotic ribosomal protein eL15 family.
  
 0.997
PH1634
142aa long hypothetical 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 0.997
PH1755
150aa long hypothetical 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
  
 0.997
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.