STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuC-2LeuC; 3-isopropylmalate dehydratase large subunit; Similar to Photorhabdus luminescens subsp. laumondii TTO1, hypothetical protein plu1869 (NCBI: NP_929137.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown. (412 aa)    
Predicted Functional Partners:
leuB
LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.998
leuD-2
LeuD; 3-isopropylmalate Dehydratase Small Subunit; Similar to Photorhabdus luminescens subsp. laumondii TTO1, hypothetical protein plu1870 (NCBI: NP_929138.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown; Belongs to the LeuD family.
 
 0.998
leuD
LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 0.997
leuA
LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.977
leuA2
LeuA2; 2-isopropylmalate synthase 2; Similar to Burkholderia oklahomensis EO147, trans-homoaconitate synthase (NCBI: ZP_02358889.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
  
 0.967
leuA-2
LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.965
leuC
LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 
0.912
poxB
PoxB; Pyruvate dehydrogenase [cytochrome]; Similar to Pantoea sp. At-9b, thiamine pyrophosphate protein TPP binding domain protein (NCBI: ZP_05728862.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Inner Membrane; Belongs to the TPP enzyme family.
 
 
 0.903
yeaU
YeaU; Probable tartrate dehydrogenase/decarboxylase; Similar to Pantoea sp. At-9b, tartrate dehydrogenase (NCBI: ZP_05732303.1); COG: Energy production and conversion; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
 
 0.890
ilvD
IlvD; Dihydroxy-acid dehydratase; Similar to Burkholderia xenovorans LB400, dihydroxy-acid dehydratase (NCBI: YP_557406.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
 
  
 0.871
Your Current Organism:
Pantoea ananatis
NCBI taxonomy Id: 706191
Other names: P. ananatis LMG 20103, Pantoea ananatis LMG 20103, Pantoea ananatis str. LMG 20103, Pantoea ananatis strain LMG 20103
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.