STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ycdL-2YcdL; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. (250 aa)    
Predicted Functional Partners:
ycdM
YcdM; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate.
 
 
 0.995
ycdJ-2
YcdJ; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
 
 0.989
ycdK
YcdK; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation.
 
 
 0.987
ycdH
YcdH; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
 
 
 0.973
hpaC
HpaC; 4-hydroxyphenylacetate 3-monooxygenase-reductase component; Similar to Bordetella avium 197N, 4-hydroxyphenylacetate 3-monooxygenase,reductase component (NCBI: YP_785494.1); COG: Energy production and conversion; Subcellular localization as predicted by Psort 2.0: Unknown.
 
 
 0.935
ycdI-2
YcdI; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted.
 
  
 0.735
ywoC
YwoC; Isochorismatase; Similar to Pantoea sp. At-9b, isochorismatase hydrolase (NCBI: ZP_05727977.1); COG: Secondary metabolites biosynthesis, transport and catabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
  
     0.622
ycdC-3
YcdC; Putative HTH-type transcriptional regulator YcdC; Similar to Serratia proteamaculans 568, TetR family transcriptional regulator (NCBI: YP_001478055.1); COG: Transcription; Subcellular localization as predicted by Psort 2.0: Unknown.
 
     0.553
ycdG
YcdG; Putative purine permease YcdG; Similar to Serratia proteamaculans 568, uracil-xanthine permease (NCBI: YP_001478049.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Inner Membrane.
  
  
 0.541
yjeF
YjeF; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX [...]
  
    0.487
Your Current Organism:
Pantoea ananatis
NCBI taxonomy Id: 706191
Other names: P. ananatis LMG 20103, Pantoea ananatis LMG 20103, Pantoea ananatis str. LMG 20103, Pantoea ananatis strain LMG 20103
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