STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)    
Predicted Functional Partners:
A0A139WF97
DNA helicase; Belongs to the MCM family.
   
0.999
D6WGF9_TRICA
DNA replication factor Cdt1-like Protein.
   
 0.999
D6WJU9_TRICA
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.999
D6WSI2_TRICA
DNA helicase; Belongs to the MCM family.
   
0.999
D6X3S8_TRICA
DNA helicase; Belongs to the MCM family.
   
0.999
D7EIV8_TRICA
DNA helicase; Belongs to the MCM family.
   
0.999
D2A4C4_TRICA
Cell division control protein 45 homolog-like Protein.
   
 0.998
D7GXT8_TRICA
MCM_N domain-containing protein.
 
 
 0.998
D6W6F1_TRICA
Minichromosome maintenance complex component 10.
   
 0.997
MCM8
DNA replication licensing factor REC-like Protein; Belongs to the MCM family.
   
0.996
Your Current Organism:
Tribolium castaneum
NCBI taxonomy Id: 7070
Other names: T. castaneum, red flour beetle, rust-red flour beetle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.