STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU47788.1COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235: IPR000277; KEGG: kfl:Kfla_1576 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. (440 aa)    
Predicted Functional Partners:
metXA
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 
 0.994
ADU48268.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.971
ADU47466.1
Cystathionine beta-synthase; COGs: COG0031 Cysteine synthase; InterProIPR001926: IPR000644: IPR005829: IPR001216: IPR 005857; KEGG: rha:RHA1_ro05843 cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein; SPTR: Putative cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase.
 
 
 0.952
ADU48833.1
Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: nca:Noca_3292 Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: Putative L,L-Cystathionine gamma-Lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
 
 
0.937
ADU47514.1
Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: nca:Noca_0976 cystathionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
 
 
0.932
ADU48014.1
Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: mmi:MMAR_3453 aminotransferase; PFAM: aminotransferase class I and II; SPTR: Putative transferase; PFAM: Aminotransferase class I and II.
   
 0.932
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
 
 
0.930
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
     
 0.917
ADU48960.1
COGs: COG0460 Homoserine dehydrogenase; InterProIPR016204: IPR019811: IPR005106: IPR001342: IPR 002912; KEGG: kra:Krad_1252 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; SPTR: Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain.
  
 
 0.866
ADU46858.1
COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR005856: IPR005859: IPR001216; KEGG: bcv:Bcav_2609 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.840
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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