STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
citECitrate lyase, beta chain (citE); Represents a citryl-ACP lyase; Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily. (291 aa)    
Predicted Functional Partners:
citXG
citG protein (citG); Bifunctional enzyme that catalyzes formation of 2-(5''- triphosphoribosyl)-3'-dephosphocoenzyme-A, and then the transfer of this prosthetic group precursor to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield the holo-acyl carrier protein. In the C-terminal section; belongs to the CitG/MdcB family.
 
  
 0.999
citF
Citrate lyase, alpha chain (citF); Represents a citrate:acetyl-ACP transferase.
 
 
 0.999
citD
Citrate lyase, gamma chain (citD); Covalent carrier of the coenzyme of citrate lyase.
 
 
 0.999
citC
Citrate lyase ligase (citC); Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
 
  
 0.979
maeB
Malate oxidoreductase, putative; Similar to GB:U00096 PID:1788806 PID:1799885 PID:1799887 percent identity: 68.69; identified by sequence similarity; putative; In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
  
 
 0.802
pta
Phosphate acetyltransferase (pta); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.701
mdh
Malate dehydrogenase (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 
 0.688
sucC
succinyl-CoA synthetase, beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
    
 0.640
HI_0082
Predicted coding region HI0082; Hypothetical protein; identified by GeneMark; putative.
  
 
 0.639
sucD
succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.623
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.