STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdaAL-serine deaminase (sdaA); Similar to GB:M28695 SP:P16095 PID:290464 GB:U00096 PID:1736451 percent identity: 68.79; identified by sequence similarity; putative. (455 aa)    
Predicted Functional Partners:
sdaC
Serine transporter (sdaC); Involved in the import of serine into the cell. Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
 
  
 0.875
glyA
Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.837
serC
Phosphoserine aminotransferase (serC); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.795
thrA
Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.754
ilvA
Threonine deaminase (ilvA); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
  
 
 0.725
trpC
Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
     
 0.716
ilvH
Acetolactate synthase III small subunit (ilvH); Similar to GB:D10483 SP:P00894 GB:X01609 PID:216495 PID:40846 percent identity: 65.62; identified by sequence similarity; putative; Belongs to the acetolactate synthase small subunit family.
  
 
 0.682
purU
Formyltetrahydrofolate deformylase (purU); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
  
  
 0.646
serB
Phosphoserine phosphatase (serB); Catalyzes the dephosphorylation of phosphoserine (P-Ser).
   
 
 0.628
thrB
Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.605
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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