node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | HI_0473 | HI_0471 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC1 | HI_0473 | HI_0470 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | Histidinol-phosphate aminotransferase (hisC); Similar to SP:P06986 GB:U02071 GB:X03416 PID:41695 PID:41710 percent identity: 60.40; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.944 |
hisA | hisC2 | HI_0473 | HI_1166 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | Histidinol-phosphate aminotransferase (hisH); Similar to SP:P17731 PID:143814 GB:AL009126 percent identity: 38.70; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.737 |
hisA | hisD | HI_0473 | HI_0469 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
hisA | hisF | HI_0473 | HI_0474 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | hisF cyclase (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.998 |
hisA | hisG | HI_0473 | HI_0468 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.991 |
hisA | hisH | HI_0473 | HI_0472 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.997 |
hisA | hisI | HI_0473 | HI_0475 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | pheA | HI_0473 | HI_1145 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | Chorismate mutase / prephenate dehydratase (pheA); Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.446 |
hisA | tyrA | HI_0473 | HI_1290 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | Chorismate mutase / prephenate dehydrogenase (tyrA); Similar to SP:Q02287 GB:M74135 GB:X60420 PID:415010 PID:43345 percent identity: 58.86; identified by sequence similarity; putative. | 0.472 |
hisB | hisA | HI_0471 | HI_0473 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative. | 0.999 |
hisB | hisC1 | HI_0471 | HI_0470 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol-phosphate aminotransferase (hisC); Similar to SP:P06986 GB:U02071 GB:X03416 PID:41695 PID:41710 percent identity: 60.40; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisC2 | HI_0471 | HI_1166 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol-phosphate aminotransferase (hisH); Similar to SP:P17731 PID:143814 GB:AL009126 percent identity: 38.70; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | HI_0471 | HI_0469 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | HI_0471 | HI_0474 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | hisF cyclase (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisB | hisG | HI_0471 | HI_0468 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.998 |
hisB | hisH | HI_0471 | HI_0472 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisB | hisI | HI_0471 | HI_0475 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisB | pheA | HI_0471 | HI_1145 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Chorismate mutase / prephenate dehydratase (pheA); Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.884 |
hisB | tyrA | HI_0471 | HI_1290 | Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Chorismate mutase / prephenate dehydrogenase (tyrA); Similar to SP:Q02287 GB:M74135 GB:X60420 PID:415010 PID:43345 percent identity: 58.86; identified by sequence similarity; putative. | 0.867 |