node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_0221.1 | HI_0692 | HI_0221.1 | HI_0692 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | 0.852 |
HI_0221.1 | gmk | HI_0221.1 | HI_1743 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | 0.826 |
HI_0221.1 | guaA | HI_0221.1 | HI_0222 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.998 |
HI_0221.1 | guaB | HI_0221.1 | HI_0221 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | Inosine-5'-monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.975 |
HI_0221.1 | hisI | HI_0221.1 | HI_0475 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family. | 0.436 |
HI_0221.1 | infB | HI_0221.1 | HI_1284 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | Translation initiation factor 2 (infB); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.871 |
HI_0221.1 | kdgK | HI_0221.1 | HI_0049 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | 2-dehydro-3-deoxygluconokinase (kdgK); Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). | 0.786 |
HI_0221.1 | purB | HI_0221.1 | HI_0639 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | 0.827 |
HI_0221.1 | purL | HI_0221.1 | HI_0752 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | Phosphoribosylformylglycinamidine synthase (purL); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.899 |
HI_0221.1 | rbsK | HI_0221.1 | HI_0505 | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | Ribokinase (rbsK); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.786 |
HI_0692 | HI_0221.1 | HI_0692 | HI_0221.1 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family. | 0.852 |
HI_0692 | gmk | HI_0692 | HI_1743 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | 0.513 |
HI_0692 | guaA | HI_0692 | HI_0222 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.934 |
HI_0692 | guaB | HI_0692 | HI_0221 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | Inosine-5'-monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.818 |
HI_0692 | hisI | HI_0692 | HI_0475 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family. | 0.705 |
HI_0692 | infB | HI_0692 | HI_1284 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | Translation initiation factor 2 (infB); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.701 |
HI_0692 | kdgK | HI_0692 | HI_0049 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | 2-dehydro-3-deoxygluconokinase (kdgK); Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). | 0.479 |
HI_0692 | purB | HI_0692 | HI_0639 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative. | 0.580 |
HI_0692 | purL | HI_0692 | HI_0752 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | Phosphoribosylformylglycinamidine synthase (purL); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.638 |
HI_0692 | rbsK | HI_0692 | HI_0505 | Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative. | Ribokinase (rbsK); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.479 |