node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_0527 | frdA | HI_0527 | HI_0835 | Ferredoxin (fdx-2); Similar to SP:P00208 percent identity: 59.49; identified by sequence similarity; putative. | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | 0.905 |
HI_0527 | mdh | HI_0527 | HI_1210 | Ferredoxin (fdx-2); Similar to SP:P00208 percent identity: 59.49; identified by sequence similarity; putative. | Malate dehydrogenase (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.600 |
HI_0527 | sucC | HI_0527 | HI_1196 | Ferredoxin (fdx-2); Similar to SP:P00208 percent identity: 59.49; identified by sequence similarity; putative. | succinyl-CoA synthetase, beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.595 |
HI_0527 | sucD | HI_0527 | HI_1197 | Ferredoxin (fdx-2); Similar to SP:P00208 percent identity: 59.49; identified by sequence similarity; putative. | succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.618 |
frdA | HI_0527 | HI_0835 | HI_0527 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | Ferredoxin (fdx-2); Similar to SP:P00208 percent identity: 59.49; identified by sequence similarity; putative. | 0.905 |
frdA | frdB | HI_0835 | HI_0834 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative. | 0.999 |
frdA | frdC | HI_0835 | HI_0833 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | Fumarate reductase, 15 kDa hydrophobic protein (frdC); Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdA | frdD | HI_0835 | HI_0832 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | Fumarate reductase, 13 kDa hydrophobic protein (frdD); Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdA | fumC | HI_0835 | HI_1398 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | Fumarate hydratase, class II (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.951 |
frdA | mdh | HI_0835 | HI_1210 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | Malate dehydrogenase (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.928 |
frdA | sdhE | HI_0835 | HI_0627 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | Conserved hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well. | 0.920 |
frdA | sucA | HI_0835 | HI_1662 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | 2-oxoglutarate dehydrogenase E1 component (sucA); E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.916 |
frdA | sucC | HI_0835 | HI_1196 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | succinyl-CoA synthetase, beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.946 |
frdA | sucD | HI_0835 | HI_1197 | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.946 |
frdB | frdA | HI_0834 | HI_0835 | Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative. | Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative. | 0.999 |
frdB | frdC | HI_0834 | HI_0833 | Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative. | Fumarate reductase, 15 kDa hydrophobic protein (frdC); Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdB | frdD | HI_0834 | HI_0832 | Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative. | Fumarate reductase, 13 kDa hydrophobic protein (frdD); Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.999 |
frdB | fumC | HI_0834 | HI_1398 | Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative. | Fumarate hydratase, class II (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.840 |
frdB | mdh | HI_0834 | HI_1210 | Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative. | Malate dehydrogenase (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.959 |
frdB | sdhE | HI_0834 | HI_0627 | Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative. | Conserved hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well. | 0.541 |