node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_0902 | lgt | HI_0902 | HI_0904 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.788 |
HI_0902 | proB | HI_0902 | HI_0900 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.553 |
HI_0902 | rppH | HI_0902 | HI_0901 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.793 |
HI_0902 | tadA | HI_0902 | HI_0906 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.762 |
HI_0902 | thyA | HI_0902 | HI_0905 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.779 |
gpsA | lgt | HI_0605 | HI_0904 | Glycerol-3-phosphate dehydrogenase (NAD+) (gpsA); Similar to SP:P37606 PID:466746 GB:U00096 PID:1657692 PID:1790037 percent identity: 66.57; identified by sequence similarity; putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.536 |
lgt | HI_0902 | HI_0904 | HI_0902 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | 0.788 |
lgt | gpsA | HI_0904 | HI_0605 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Glycerol-3-phosphate dehydrogenase (NAD+) (gpsA); Similar to SP:P37606 PID:466746 GB:U00096 PID:1657692 PID:1790037 percent identity: 66.57; identified by sequence similarity; putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.536 |
lgt | lspA | HI_0904 | HI_1006 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Lipoprotein signal peptidase (lspA); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.509 |
lgt | proB | HI_0904 | HI_0900 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.593 |
lgt | rppH | HI_0904 | HI_0901 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.788 |
lgt | tadA | HI_0904 | HI_0906 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Conserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.783 |
lgt | thyA | HI_0904 | HI_0905 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.800 |
lgt | trpA | HI_0904 | HI_1432 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Tryptophan synthase alpha subunit (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.717 |
lgt | trpB | HI_0904 | HI_1431 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Tryptophan synthase beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.713 |
lgt | yidC | HI_0904 | HI_1001 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Inner membrane protein, 60 kDa (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.760 |
lspA | lgt | HI_1006 | HI_0904 | Lipoprotein signal peptidase (lspA); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.509 |
lspA | yidC | HI_1006 | HI_1001 | Lipoprotein signal peptidase (lspA); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Inner membrane protein, 60 kDa (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.536 |
proB | HI_0902 | HI_0900 | HI_0902 | Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | 0.553 |
proB | lgt | HI_0900 | HI_0904 | Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.593 |