STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dmsAAnaerobic dimethyl sulfoxide reductase, chain A (dmsA); Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (806 aa)    
Predicted Functional Partners:
dmsB
Anaerobic dimethyl sulfoxide reductase, chain B (dmsB); Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.
 0.995
dmsC
Anaerobic dimethyl sulfoxide reductase, chain C (dmsC); Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it (By similarity).
 
 0.972
dmsD
Conserved hypothetical protein; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding- maturation pathway for the substrate protein.
 
 0.963
nrfC
Nitrite reductase, Fe-S protein (nrfC); Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes.
 
 0.943
napB
Periplasmic nitrate reductase (napB); Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane-anchored tetraheme c-type NapC protein and transfers these to NapA subunit, thus allowing electron flow between membrane and periplasm. Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor; Belongs to the NapB family.
  
 0.852
napD
napD protein (napD); Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
  
 
 0.840
napF
Ferredoxin-type protein (napF); Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family.
  
 
 0.839
napG
Ferredoxin-type protein (napG); Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.
 
  0.833
fdxH
Formate dehydrogenase, beta subunit (fdxH); Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).
 
 0.829
torY
Cytochrome C-type protein (yecK); Part of the anaerobic respiratory chain of trimethylamine-N- oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme (By similarity).
  
 0.826
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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