STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rfaFADP-heptose--LPS heptosyltransferase II (rfaF); Similar to SP:P37692 PID:466758 GB:U00096 PID:1790050 percent identity: 63.58; identified by sequence similarity; putative. (346 aa)    
Predicted Functional Partners:
gmhB
Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate, phospho-serine and fructose-1,6-biphosphate in vitro. Belongs to the GmhB family.
  
 0.942
hldE
ADP-heptose synthase (rfaE); Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
 
 
 0.914
opsX
Lipopolysaccharide biosynthesis protein, putative; Catalyzes heptose transfer to the lipopolysaccharide core. It transfers the first L-glycero-D-manno-heptose to the phosphorylated 3- deoxy-alpha-D-manno-octulosonic acid (Kdo-P) of the inner core. Belongs to the glycosyltransferase 9 family.
 
 
0.908
hldD
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
 
  
 0.877
HI_0523
Conserved hypothetical protein; Similar to GB:AE000511 PID:2314449 percent identity: 36.28; identified by sequence similarity; putative; Belongs to the glycosyltransferase 9 family.
 
 
 0.830
waaA
3-deoxy-d-manno-octulosonic-acid transferase (kdtA); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'- bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily.
 
  
 0.761
HI_0874
Predicted coding region HI0874; Hypothetical protein; identified by GeneMark; putative.
 
 
 0.712
gmhA
Phosphoheptose isomerase (gmhA); Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
 
  
 0.700
HI_1657
Conserved hypothetical protein; Similar to SP:P45466 PID:606089 GB:U00096 PID:1789539 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the SIS family. DiaA subfamily.
 
  
 0.687
kdkA
Predicted coding region HI0260.1; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position. To a lesser extent, can use GTP instead of ATP as substrate.
   
 0.668
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.