STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
neuAAcylneuraminate cytidylyltransferase (neuA); Similar to GB:M95053 GB:X78068 GB:U04328 PID:460146 PID:520734 percent identity: 47.06; identified by sequence similarity; putative; Belongs to the CMP-NeuNAc synthase family. (228 aa)    
Predicted Functional Partners:
HI_1679
Conserved hypothetical protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
 
  0.971
kdsB
3-deoxy-D-manno-octulosonate cytidylyltransferase (kdsB); Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
  
  0.627
nanA
N-acetylneuraminate lyase (nanA); Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate; Belongs to the DapA family. NanA subfamily.
   
 
 0.627
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase (kdsA); Similar to SP:P17579 GB:X05552 PID:940498 PID:968934 GB:U00096 percent identity: 81.63; identified by sequence similarity; putative; Belongs to the KdsA family.
    
  0.597
nanK
Glucose kinase, putative; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily.
  
   
 0.558
HI_1278
NAD(P)H-flavin oxidoreductase; Similar to GB:D17743 SP:P46072 PID:517169 percent identity: 33.33; identified by sequence similarity; putative.
       0.543
HI_1556
2-hydroxyacid dehydrogenase; Similar to GB:AE000511 PID:2313177 percent identity: 41.64; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
      0.539
nanE
Conserved hypothetical protein; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
      
 0.437
HI_1280
Conserved hypothetical protein; Similar to GB:M29945 PID:1197032 percent identity: 50.43; identified by sequence similarity; putative.
       0.401
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.