node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HI_1171 | aroC | HI_1171 | HI_0196 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.727 |
HI_1171 | pheA | HI_1171 | HI_1145 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Chorismate mutase / prephenate dehydratase (pheA); Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.870 |
HI_1171 | trpA | HI_1171 | HI_1432 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Tryptophan synthase alpha subunit (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.934 |
HI_1171 | trpB | HI_1171 | HI_1431 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Tryptophan synthase beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.898 |
HI_1171 | trpC | HI_1171 | HI_1389.1 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.999 |
HI_1171 | trpD | HI_1171 | HI_1389 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Anthanilate phosphoribosyltransferase (trpD); Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.997 |
HI_1171 | trpE | HI_1171 | HI_1387 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Anthranilate synthase component I (trpE); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] | 0.998 |
HI_1171 | trpG | HI_1171 | HI_1388 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Anthranilate synthase component II (trpG); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] | 0.642 |
HI_1171 | tyrA | HI_1171 | HI_1290 | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | Chorismate mutase / prephenate dehydrogenase (tyrA); Similar to SP:Q02287 GB:M74135 GB:X60420 PID:415010 PID:43345 percent identity: 58.86; identified by sequence similarity; putative. | 0.821 |
aroC | HI_1171 | HI_0196 | HI_1171 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative. | 0.727 |
aroC | guaA | HI_0196 | HI_0222 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.611 |
aroC | pheA | HI_0196 | HI_1145 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase / prephenate dehydratase (pheA); Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.935 |
aroC | trpA | HI_0196 | HI_1432 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase alpha subunit (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.700 |
aroC | trpB | HI_0196 | HI_1431 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.540 |
aroC | trpC | HI_0196 | HI_1389.1 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.880 |
aroC | trpD | HI_0196 | HI_1389 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthanilate phosphoribosyltransferase (trpD); Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.783 |
aroC | trpE | HI_0196 | HI_1387 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I (trpE); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] | 0.759 |
aroC | trpG | HI_0196 | HI_1388 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component II (trpG); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] | 0.736 |
aroC | tyrA | HI_0196 | HI_1290 | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase / prephenate dehydrogenase (tyrA); Similar to SP:Q02287 GB:M74135 GB:X60420 PID:415010 PID:43345 percent identity: 58.86; identified by sequence similarity; putative. | 0.996 |
guaA | aroC | HI_0222 | HI_0196 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.611 |