Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

HI_1453

Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family (156 aa)

Predicted Functional Partners:

msrAB

0.995

HI_1454

0.990

purN

0.901

purM

0.900

nrfF

0.660

dsbD

0.485

PGdx

0.469

HI_1452

0.445

HI_1457

0.405

HI_1456

0.405

Your Current Organism:

Haemophilus influenzae

NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HI_1452	HI_1453	HI_1452	HI_1453	Putative lysine exporter; Mediates export of lysine	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	0.445
HI_1453	HI_1452	HI_1453	HI_1452	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Putative lysine exporter; Mediates export of lysine	0.445
HI_1453	HI_1454	HI_1453	HI_1454	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Putative cytochrome c-type biogenesis protein HI_1454; Could be involved in cytochrome c synthesis	0.990
HI_1453	HI_1456	HI_1453	HI_1456	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Uncharacterized protein HI_1456; Hypothetical protein; identified by GeneMark; putative	0.405
HI_1453	HI_1457	HI_1453	HI_1457	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Uncharacterized protein HI_1457; Similar to PID-2367659 percent identity- 34.32; identified by sequence similarity; putative; Belongs to the opacity porin family	0.405
HI_1453	PGdx	HI_1453	HI_0572	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Hybrid peroxiredoxin hyPrx5; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family	0.469
HI_1453	dsbD	HI_1453	HI_0885	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Thiol-disulfide interchange protein DsbD; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)	0.485
HI_1453	msrAB	HI_1453	HI_1455	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Peptide methionine sulfoxide reductase MsrA/MsrB; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)	0.995
HI_1453	nrfF	HI_1453	HI_0934	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Formate-dependent nitrite reductase complex bifunctional subunit NrfFG; Possible subunit of a heme lyase	0.660
HI_1453	purM	HI_1453	HI_1429	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB-M13747 SP-P08178 PID-147425 GB-U00096 PID-1788845 percent identity- 76.30; identified by sequence similarity; putative	0.900
HI_1453	purN	HI_1453	HI_1428	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	0.901
HI_1454	HI_1453	HI_1454	HI_1453	Putative cytochrome c-type biogenesis protein HI_1454; Could be involved in cytochrome c synthesis	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	0.990
HI_1454	HI_1456	HI_1454	HI_1456	Putative cytochrome c-type biogenesis protein HI_1454; Could be involved in cytochrome c synthesis	Uncharacterized protein HI_1456; Hypothetical protein; identified by GeneMark; putative	0.469
HI_1454	HI_1457	HI_1454	HI_1457	Putative cytochrome c-type biogenesis protein HI_1454; Could be involved in cytochrome c synthesis	Uncharacterized protein HI_1457; Similar to PID-2367659 percent identity- 34.32; identified by sequence similarity; putative; Belongs to the opacity porin family	0.469
HI_1454	msrAB	HI_1454	HI_1455	Putative cytochrome c-type biogenesis protein HI_1454; Could be involved in cytochrome c synthesis	Peptide methionine sulfoxide reductase MsrA/MsrB; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)	0.997
HI_1454	nrfF	HI_1454	HI_0934	Putative cytochrome c-type biogenesis protein HI_1454; Could be involved in cytochrome c synthesis	Formate-dependent nitrite reductase complex bifunctional subunit NrfFG; Possible subunit of a heme lyase	0.452
HI_1456	HI_1453	HI_1456	HI_1453	Uncharacterized protein HI_1456; Hypothetical protein; identified by GeneMark; putative	Uncharacterized protein HI_1453; Similar to GB-AL009126 percent identity- 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family	0.405
HI_1456	HI_1454	HI_1456	HI_1454	Uncharacterized protein HI_1456; Hypothetical protein; identified by GeneMark; putative	Putative cytochrome c-type biogenesis protein HI_1454; Could be involved in cytochrome c synthesis	0.469
HI_1456	HI_1457	HI_1456	HI_1457	Uncharacterized protein HI_1456; Hypothetical protein; identified by GeneMark; putative	Uncharacterized protein HI_1457; Similar to PID-2367659 percent identity- 34.32; identified by sequence similarity; putative; Belongs to the opacity porin family	0.845
HI_1456	msrAB	HI_1456	HI_1455	Uncharacterized protein HI_1456; Hypothetical protein; identified by GeneMark; putative	Peptide methionine sulfoxide reductase MsrA/MsrB; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)	0.473

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