Groups of genes that are frequently observed in each other's genomic neighborhood.
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Experiments
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Q5TQJ1_ANOGA
Tetraspanin. (234 aa)
Predicted Functional Partners:
snmp1
Sensory neuron membrane protein 1; Plays an olfactory role that is not restricted to pheromone sensitivity.
0.594
A7UTV1_ANOGA
AGAP005731-PA.
0.449
D1.1
Actin, cytoplasmic.
0.427
Your Current Organism:
Anopheles gambiae
NCBI taxonomy Id: 7165 Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto