STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Def1Defensin; Responsible for the anti Gram-positive activity of immune hemolymph; Belongs to the invertebrate defensin family. Type 1 subfamily. (102 aa)    
Predicted Functional Partners:
gambif1
AGAP009515-PA.
     
 0.956
CecA
Cecropin-A amidated isoform; Antibacterial activity against several Gram-positive and Gram-negative bacteria. Antifungal activity against A.fumigatus, B.cinerea, F.culmorum, F.oxysporum, N.crassa, C.albicans, C.neoformans and S.cerevisiae.
   
  
 0.891
irsp
Putative infection responsive short peptide.
      
 0.730
IMD
IMD pathway signalling Immune Deficiency (Imd).
      
 0.723
CecB
Cecropin-B; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family.
      
 0.620
REL2
IMD pathway signalling NF-kappaB Relish-like transcription factor.
      
 0.611
CEC4
Cecropin anti-microbial peptide.
      
 0.579
DEF2
Defensin anti-microbial peptide.
      
 0.577
PGRPLC
Peptidoglycan recognition protein (long).
      
 0.416
Your Current Organism:
Anopheles gambiae
NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto
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