Groups of genes that are frequently observed in each other's genomic neighborhood.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0NGM4_ANOGA
AGAP012068-PA; Belongs to the peptidase C2 family. (815 aa)
Predicted Functional Partners:
Q7PP27_ANOGA
AGAP006246-PA.
0.558
Q5TQV7_ANOGA
Small calcium-binding mitochondrial carrier protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family.
0.487
Your Current Organism:
Anopheles gambiae
NCBI taxonomy Id: 7165 Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto