node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECL_00270 | ECL_01482 | ECL_00270 | ECL_01482 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 23S rRNA methyltransferase A. | 0.683 |
ECL_00270 | bioB | ECL_00270 | ECL_02961 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.417 |
ECL_00270 | entF | ECL_00270 | ECL_03114 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Enterobactin synthase subunit F; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.783 |
ECL_00270 | gcvP | ECL_00270 | ECL_04230 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.555 |
ECL_01480 | ECL_01482 | ECL_01480 | ECL_01482 | Cold shock-like protein cspC. | 23S rRNA methyltransferase A. | 0.503 |
ECL_01480 | ftsI-2 | ECL_01480 | ECL_01481 | Cold shock-like protein cspC. | Peptidoglycan synthetase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | 0.458 |
ECL_01482 | ECL_00270 | ECL_01482 | ECL_00270 | 23S rRNA methyltransferase A. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.683 |
ECL_01482 | ECL_01480 | ECL_01482 | ECL_01480 | 23S rRNA methyltransferase A. | Cold shock-like protein cspC. | 0.503 |
ECL_01482 | ECL_02527 | ECL_01482 | ECL_02527 | 23S rRNA methyltransferase A. | FAD-dependent pyridine nucleotide-disulfide oxidoreductase. | 0.436 |
ECL_01482 | aas | ECL_01482 | ECL_04157 | 23S rRNA methyltransferase A. | 2-acylglycerophosphoethanolamine acyltransferase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | 0.818 |
ECL_01482 | bioA | ECL_01482 | ECL_02962 | 23S rRNA methyltransferase A. | Adenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.464 |
ECL_01482 | bioB | ECL_01482 | ECL_02961 | 23S rRNA methyltransferase A. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.551 |
ECL_01482 | dapE | ECL_01482 | ECL_03769 | 23S rRNA methyltransferase A. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.681 |
ECL_01482 | entF | ECL_01482 | ECL_03114 | 23S rRNA methyltransferase A. | Enterobactin synthase subunit F; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.842 |
ECL_01482 | ftsI-2 | ECL_01482 | ECL_01481 | 23S rRNA methyltransferase A. | Peptidoglycan synthetase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | 0.637 |
ECL_01482 | gcvP | ECL_01482 | ECL_04230 | 23S rRNA methyltransferase A. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.837 |
ECL_02527 | ECL_01482 | ECL_02527 | ECL_01482 | FAD-dependent pyridine nucleotide-disulfide oxidoreductase. | 23S rRNA methyltransferase A. | 0.436 |
aas | ECL_01482 | ECL_04157 | ECL_01482 | 2-acylglycerophosphoethanolamine acyltransferase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | 23S rRNA methyltransferase A. | 0.818 |
aas | bioA | ECL_04157 | ECL_02962 | 2-acylglycerophosphoethanolamine acyltransferase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Adenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.551 |
aas | entF | ECL_04157 | ECL_03114 | 2-acylglycerophosphoethanolamine acyltransferase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. | Enterobactin synthase subunit F; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.982 |