STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ91179.1KEGG: mmw:Mmwyl1_2369 DNA ligase; PFAM: DNA ligase, ATP-dependent, central. (275 aa)    
Predicted Functional Partners:
ADZ89308.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.982
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
    
 0.916
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.905
ADZ91532.1
KEGG: mmw:Mmwyl1_2266 DNA polymerase III subunit delta'; manually curated; TIGRFAM: DNA polymerase III, delta prime subunit.
   
 0.889
ADZ91386.1
KEGG: mmw:Mmwyl1_2210 DNA polymerase II; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B.
   
 0.884
ADZ90711.1
KEGG: mmw:Mmwyl1_2881 5'-3' exonuclease; PFAM: 5'-3' exonuclease, SAM-fold domain; 5'-3' exonuclease, alpha-helical arch, N-terminal; SMART: 5'-3' exonuclease, N-terminal; Helix-hairpin-helix motif, class 2.
  
 0.797
ADZ91566.1
SMC domain protein; PFAM: RecF/RecN/SMC; KEGG: mmw:Mmwyl1_2355 SMC domain-containing protein.
   
 0.794
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.789
ADZ90388.1
KEGG: mmw:Mmwyl1_1245 signal peptidase I; TIGRFAM: Peptidase S26A, signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; Belongs to the peptidase S26 family.
    
 0.781
ADZ91180.1
Manually curated; KEGG: mmw:Mmwyl1_2368 alpha/beta hydrolase fold.
       0.768
Your Current Organism:
Marinomonas mediterranea
NCBI taxonomy Id: 717774
Other names: M. mediterranea MMB-1, Marinomonas mediterranea MMB-1, Marinomonas mediterranea str. MMB-1, Marinomonas mediterranea strain MMB-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.