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STRINGSTRING
fd19B protein (fruit fly) - STRING interaction network
"fd19B" - Forkhead domain 19B in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
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Databases
Textmining
[Homology]
Score
fd19BForkhead domain 19B; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; transcription factor binding; DNA binding, bending (260 aa)    
Predicted Functional Partners:
slp2
Sloppy paired 2 (Slp2) is a transcription factor of the fork-head family. Together with slp1, Slp2 regulates a wide variety of developmental processes including embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons (451 aa)
         
0.817
Sir2
NAD-dependent histone deacetylase Sir2; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin- mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span (823 aa)
       
 
  0.683
CG42741
Uncharacterized protein; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; metal ion binding. It is involved in the biological process described with- regulation of transcription, DNA-templated; neurogenesis (362 aa)
       
 
  0.575
oc
Homeotic protein ocelliless; Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression- essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors; Belongs to the paired homeobox family (548 aa)
     
 
  0.510
l(1)sc
Achaete-scute complex protein T3; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system (257 aa)
     
 
  0.495
dmrt11E
Doublesex-Mab related 11E is a transcription factor-like protein containing a highly conserved DNA-binding DM domain that plays a critical role in sex determination and spermatogenesis (377 aa)
       
 
  0.484
Cdk8
Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C-terminal domain) of the [...] (454 aa)
     
 
  0.482
nej
Nejire, isoform C; Nejire encodes the transcriptional co-activator CBP. It acetylates several nuclear proteins, including histone H3 on K18, K27, and H4 on K8. By regulating gene expression, CBP has roles in cell proliferation, cell signaling and differentiation, and in developmental patterning (3282 aa)
     
 
  0.481
bs
Serum response factor homolog; Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea (449 aa)
       
 
  0.480
gro
Groucho (Gro) is a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. Groucho functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of Gro in response to MAPK activation weakens its repressor capacity (730 aa)
     
 
  0.472
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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