STRINGSTRING
fd19B protein (fruit fly) - STRING interaction network
"fd19B" - Forkhead domain 19B in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fd19BForkhead domain 19B (260 aa)    
Predicted Functional Partners:
cdc2c
Cdc2c; Like Cdk1, could play a key role in the control of the eukaryotic cell cycle (314 aa)
     
  0.697
cdc2
Cdc2; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (297 aa)
     
  0.697
OdsH
Ods-site homeobox (382 aa)
       
  0.602
unc-4
Unc-4; Transcription factor that regulates synaptic specificity (428 aa)
       
  0.580
Gsc
Goosecoid; Appears to regulate regional development of specific tissues. Can rescue axis polarity in UV-radiated Xenopus embryos (485 aa)
       
  0.578
bs
Blistered; Required for the formation of intervein tissue of the wing. Acts in a dosage-dependent manner to suppress wing vein formation and promote development of intervein cells. Might play a role in the proper formation and maintenance of the trachea (449 aa)
       
  0.577
Sir2
Sir2; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin- mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span (823 aa)
       
  0.554
SAK
Sak kinase; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centroso [...] (769 aa)
     
  0.546
polo
Polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (576 aa)
     
  0.546
CG11294
Sequence-specific DNA binding transcription factor activity (261 aa)
       
  0.518
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: medium (60%) [HD]