STRINGSTRING
alpha-Cat protein (fruit fly) - STRING interaction network
"alpha-Cat" - Alpha Catenin in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alpha-CatAlpha Catenin; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with the armadillo protein (917 aa)    
Predicted Functional Partners:
arm
Armadillo; Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (843 aa)
     
  0.999
shg
Shotgun; Cadherins are calcium-dependent cell adhesion proteins (PubMed-7958432). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed-7958432). N-cadherin may be involved in neuronal recognition mechanism (PubMed-7958432). May function in cell intercalation in the lateral epidermis during germband extension (PubMed-24681004) (1507 aa)
     
  0.997
Vinc
Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane (By similarity) (961 aa)
     
0.984
Ank
Ankyrin (1549 aa)
     
 
  0.983
p120ctn
Adherens junction protein p120 (781 aa)
     
  0.981
sxc
Super sex combs (1059 aa)
     
   
  0.966
eIF4G
Eukaryotic translation initiation factor 4G (1919 aa)
     
        0.963
rhea
Rhea (2836 aa)
     
  0.950
Zyx
Zyxin (585 aa)
     
  0.947
CG10417
Protein serine/threonine phosphatase activity (662 aa)
     
        0.933
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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