STRINGSTRING
CG33217 protein (fruit fly) - STRING interaction network
"CG33217" - RE15216p in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG33217RE15216p (699 aa)    
Predicted Functional Partners:
Haspin
Haspin (566 aa)
     
        0.786
CG32075
LD47413p (541 aa)
     
 
  0.758
nej
Nejire (3282 aa)
       
  0.689
drk
Downstream of receptor kinase; Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (211 aa)
     
 
    0.666
Tif-IA
Tif-IA (611 aa)
     
        0.647
CG10395
Uncharacterized protein, isoform D (313 aa)
     
        0.640
Src42A
Src oncogene at 42A; Essential for correct eye morphogenesis (ommatidial R7 neuron formation), this requires the Ras1/MAPK signal transduction pathway (PubMed-8682295). May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia (PubMed-8682295). During embryogenesis, involved in regulation of dorsal closure (PubMed-16831834). It may have a role in activating the JNK pathway in leading edge cells during dorsal closure (PubMed-16831834) (517 aa)
     
  0.591
Akt1
Akt1; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. May also stimulate cell growth b [...] (611 aa)
     
 
  0.585
Src64B
Src oncogene at 64B; May play a role in the development of neural tissue and smooth muscle (552 aa)
     
  0.580
Ras85D
Protein binding; May mediate a signal that determines the fate of photoreceptor cells in the developing compound eye. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
     
 
    0.576
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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