STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GCS2alphaGlucan 1,3-alpha-glucosidase activity; carbohydrate binding. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 31 family. (924 aa)    
Predicted Functional Partners:
GCS2beta
Glucosidase 2 beta subunit, isoform A; It is involved in the biological process described with: N-glycan processing.
 
 
 0.995
GCS1
Glucosidase 1, isoform B; Mannosyl-oligosaccharide glucosidase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide metabolic process.
   
 0.983
alpha-Man-Ib
alpha-1,2-Mannosidase; Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding. It is involved in the biological process described with: encapsulation of foreign target; N-glycan processing; ubiquitin-dependent ERAD pathway; Belongs to the glycosyl hydrolase 47 family.
   
 
 0.955
CG7685
RE55916p; It is involved in the biological process described with: N-glycan processing.
   
 
 0.932
CG32857
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins; Belongs to the NifU family.
      
 0.836
CG9485
Uncharacterized protein, isoform B; 4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity. It is involved in the biological process described with: glycogen biosynthetic process; glycogen catabolic process.
  
 
 0.825
CG32819
LD08455p; Structural constituent of cytoskeleton. It is involved in the biological process described with: flagellated sperm motility; microtubule nucleation.
 
    
 0.821
Uggt
UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family.
   
 
 0.802
Cnx99A
Calnexin 99A (Cnx99A) encodes an endoplasmic reticulum chaperone that colocalizes and genetically interacts with the sodium channel subunit encoded by para.
   
 
 0.797
Ostgamma
Oligosaccharide transferase gamma subunit (Ostgamma) encodes a subunit of the oligosaccharyltransferase complex involved in cell migration and cellular encapsulation response.
   
 
 0.796
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.