STRINGSTRING
y protein (fruit fly) - STRING interaction network
"y" - Yellow in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
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[Homology]
Score
yYellow; Controls the pigmentation pattern of the adult cuticle and larval mouth parts (541 aa)    
Predicted Functional Partners:
su(Hw)
Suppressor of Hairy wing; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into i [...] (941 aa)
       
 
  0.732
e
Ebony (879 aa)
       
 
  0.725
mod(mdg4)
Modifier of mdg4 (666 aa)
       
      0.711
ph-p
Polyhomeotic proximal; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-118’, rendering chromatin heritably changed in its expressibility. Plays a role in regulatin [...] (1589 aa)
       
      0.711
su(s)
RNA binding; Affects the transcript levels of those alleles that it suppresses. May be involved in influencing complex assembly on cryptic 5’-splice sites or nuclear RNA export; binds RNA preferentially at a sequence that resembles a cryptic 5’-splice site (in vitro) (1325 aa)
       
      0.711
e(y)1
Enhancer of yellow 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (278 aa)
       
      0.676
z
Zeste; Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter (605 aa)
       
 
  0.613
sn
Singed; Probably acts as an actin bundling protein. May have a role in the asymmetric organization and/or movement of cytoplasmic components. It has a role in somatic cells during the formation of adult bristles and hairs, and in the female germline during oogenesis (512 aa)
       
      0.613
e(y)2
Enhancer of yellow 2; Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in transcription elongati [...] (101 aa)
       
      0.613
CG9674
Glutamate synthase (NADPH) activity (2115 aa)
     
   
  0.504
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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