STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argArginase (arg) encodes an enzyme that converts arginine into ornithine. Lack of arg produces a developmental embryonic delay. (351 aa)    
Predicted Functional Partners:
Oat
Ornithine aminotransferase, mitochondrial; Ornithine-oxo-acid transaminase activity; identical protein binding; pyridoxal phosphate binding. It is involved in the biological process described with: arginine catabolic process to proline via ornithine; ornithine metabolic process; arginine catabolic process to glutamate.
  
 0.995
Odc2
Ornithine decarboxylase 2; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family.
  
 
 0.986
Odc1
Ornithine decarboxylase 1; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
  
 
 0.985
Argl
Argininosuccinate lyase activity. It is involved in the biological process described with: arginine biosynthetic process via ornithine.
     
 0.969
SpdS
Spermidine synthase activity. It is involved in the biological process described with: polyamine biosynthetic process; spermidine biosynthetic process; Belongs to the spermidine/spermine synthase family.
  
  
 0.963
Nos
Nitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family.
    
 0.958
SamDC
S-adenosylmethionine decarboxylase (SamDC) encodes a protein involved in defense response to Gram-negative bacterium; Belongs to the eukaryotic AdoMetDC family.
   
  
 0.941
CG6733
RE20374p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process.
  
 
 0.927
CG6465
GH04054p; Metallopeptidase activity; aminoacylase activity. It is involved in the biological process described with: proteolysis; cellular amino acid metabolic process.
  
 
 0.926
CG6738
FI02833p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process.
  
 
 0.926
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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