STRINGSTRING
l(1)1Bi protein (fruit fly) - STRING interaction network
"l(1)1Bi" - Lethal in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
l(1)1BiLethal (1) 1Bi (1133 aa)    
Predicted Functional Partners:
CG30349
FI03455p (620 aa)
     
 
  0.986
l(2)k09022
Lethal (2) k09022; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) (2096 aa)
     
 
  0.984
Mat89Ba
RNA binding (1193 aa)
     
   
  0.980
l(1)G0020
Lethal (1) G0020; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)- acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptional [...] (1008 aa)
     
        0.979
RpI135
RNA polymerase I 135kD subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) (1129 aa)
     
   
  0.973
CG5033
Ribonucleoprotein complex binding; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit (784 aa)
     
 
  0.973
CG5728
mRNA binding (1430 aa)
     
        0.973
CG12325
LD10780p (949 aa)
     
   
  0.969
CG8064
CG8064 (922 aa)
     
   
  0.969
CG7338
Tsr1 ribosome assembly factor; Required during maturation of the 40S ribosomal subunit in the nucleolus (814 aa)
     
        0.968
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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