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skpA protein (fruit fly) - STRING interaction network
skpA in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
skpAskpA (162 aa)    
Predicted Functional Partners:
lin19
Lin-19-like; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval dda [...] (774 aa)
     
  0.999
Roc1a
Roc1a (136 aa)
     
  0.999
ago
Archipelago; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Involved in the degradation of cyclin E and dm/Myc. Required for endocycles, but not mitosis in follicle cell epithelium (1326 aa)
       
  0.999
Skp2
CG9772 gene product from transcript CG9772-RA (581 aa)
     
  0.999
Cks85A
Cyclin-dependent kinase subunit 85A; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (96 aa)
       
  0.998
slmb
Supernumerary limbs (597 aa)
       
  0.997
Fsn
Protein binding; Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation (255 aa)
     
  0.996
Kdm2
Lysine (K)-specific demethylase 2; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code (1345 aa)
       
  0.996
Roc1b
Roc1b; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity) (122 aa)
     
  0.994
CG11700
Uncharacterized protein (301 aa)
     
  0.994
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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