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STRINGSTRING
fs(1)N protein (fruit fly) - STRING interaction network
"fs(1)N" - Female sterile in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fs(1)NFemale sterile (1) Nasrat, fs(1)M3 and clos are mutually required for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation (2118 aa)    
Predicted Functional Partners:
trk
Protein trunk; Required for activity of the tor receptor, could be a ligand of tor. Involved in specifying terminal body pattern (235 aa)
         
  0.842
tsl
Torso-like is present in many organs of Drosophila. In particular it is produced and secreted by two cell clusters in the egg chamber, initially anchored at the vitelline membrane and then translocated to the oocyte plasma membrane where it is required for the trk-mediated activation of the tor receptor (353 aa)
       
 
  0.752
yl
Putative vitellogenin receptor; Involved in uptake of vitellogenin by endocytosis (1984 aa)
     
   
  0.698
clos
Closca, fs(1)N and fs(1)M3 are mutually required for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation (1836 aa)
     
   
  0.693
fs(1)M3
Female sterile (1) M3, fs(1)N and clos are mutually required for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation (1836 aa)
     
   
0.632
otu
Protein ovarian tumor locus; Essential for female fertility; germ cell division and differentiation (853 aa)
     
        0.598
Pxt
Chorion peroxidase; Peroxinectin-like (Pxt) is a cycloxygenase-like enzyme that contributes to the synthesis of prostaglandins. Prostaglandins activate G protein-coupled receptor signaling. Pxt roles include oogenesis, sperm individualization, morphogenesis, nucleolar structure, temporal control of gene expression, and regulation of gene amplification; Belongs to the peroxidase family. XPO subfamily (809 aa)
     
   
  0.569
mRNA-cap
mRNA-capping enzyme; Bifunctional mRNA-capping enzyme exhibiting RNA 5’- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation- by removing the gamma-phosphate from the 5’-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5’-diphosphate terminus (649 aa)
           
  0.485
piwi
Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael- dependent manner. [...] (843 aa)
     
   
  0.482
CG11378
annotation not available (312 aa)
           
  0.482
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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