STRINGSTRING
SNF1A protein (fruit fly) - STRING interaction network
SNF1A/AMP-activated protein kinase in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SNF1ASNF1A/AMP-activated protein kinase (582 aa)    
Predicted Functional Partners:
SNF4Agamma
AMP-activated protein kinase activity (1400 aa)
     
  0.999
alc
Alicorn (341 aa)
     
  0.999
gig
Gigas (1847 aa)
     
  0.992
raptor
Raptor (1621 aa)
     
  0.991
ACC
Acetyl-CoA carboxylase (2571 aa)
     
  0.987
Tor
Target of rapamycin; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiation. Hyperactiva [...] (2470 aa)
     
  0.984
foxo
Forkhead box, sub-group O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself [...] (622 aa)
     
  0.977
Tsc1
Tsc1 (1100 aa)
     
 
  0.975
Rheb
Rheb; Binds GTP and exhibits intrinsic GTPase activity (182 aa)
     
  0.975
lkb1
Lkb1 (567 aa)
     
0.969
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: medium (52%) [HD]