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STRINGSTRING
eIF4E-7 protein (fruit fly) - STRING interaction network
"eIF4E-7" - Protein binding in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eIF4E-7Protein binding; RNA 7-methylguanosine cap binding; eukaryotic initiation factor 4G binding; RNA cap binding; translation initiation factor activity. It is involved in the biological process described with- translational initiation (429 aa)    
Predicted Functional Partners:
eIF4G
RNA 7-methylguanosine cap binding; RNA binding; translation initiation factor activity; eukaryotic initiation factor 4E binding. It is involved in the biological process described with- mitotic nuclear division; translational initiation; mitotic spindle elongation; translation; mitotic spindle organization; mitotic G2 DNA damage checkpoint; G1/S transition of mitotic cell cycle (1919 aa)
     
  0.999
Thor
4E-binding protein THOR; Thor is a eukaryotic translation initiation factor 4E binding protein that is controlled by tor. It contributes to translation regulation, response to environmental stress and cell growth regulation (117 aa)
       
  0.998
eIF-4a
Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation (403 aa)
     
  0.994
eIF-4B
mRNA binding; translation initiation factor activity; nucleotide binding. It is involved in the biological process described with- translational initiation; positive regulation of JAK-STAT cascade; cell proliferation (459 aa)
     
  0.989
eIF4AIII
Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. Has a role in oskar mRNA localization at the posterior pole of the developing oocyte (399 aa)
     
  0.987
eIF4G2
RNA 7-methylguanosine cap binding; translation initiation factor activity. It is involved in the biological process described with- translational initiation; autophagic cell death; male meiosis; spermatogenesis; salivary gland cell autophagic cell death; spermatid differentiation; G1/S transition of mitotic cell cycle; meiotic G2/MI transition (2072 aa)
     
  0.986
RpS6
40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (248 aa)
     
  0.984
eIF3-S9
Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (690 aa)
     
  0.979
raptor
Raptor, isoform B; It is involved in the biological process described with- oogenesis; cellular response to DNA damage stimulus; TOR signaling; positive regulation of protein phosphorylation; negative regulation of synaptic growth at neuromuscular junction; axon guidance (1621 aa)
       
  0.977
eIF-2alpha
Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region (341 aa)
     
  0.973
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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