STRINGSTRING
eIF4E-7 protein (fruit fly) - STRING interaction network
eIF4E-7 in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eIF4E-7eIF4E-7 (429 aa)    
Predicted Functional Partners:
Thor
Thor (117 aa)
       
  0.999
eIF4G
Eukaryotic translation initiation factor 4G (1919 aa)
     
  0.999
eIF4G2
RNA 7-methylguanosine cap binding (2072 aa)
     
  0.996
eIF4AIII
eIF4AIII; ATP-dependent RNA helicase (PubMed-22961380). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed-14973490, PubMed-22961380). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed-20946982, PubMed-20946983). Has a role in oskar mRNA localization at the posterior pole of the developing oocyte (PubMed-14973490) (399 aa)
     
  0.995
eIF-4a
Eukaryotic initiation factor 4a; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation (403 aa)
     
  0.994
Tor
Target of rapamycin; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiation. Hyperactiva [...] (2470 aa)
     
  0.992
eIF-2alpha
Translation initiation factor activity; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region (341 aa)
     
  0.990
RpS6
Ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (248 aa)
     
  0.989
raptor
Raptor (1621 aa)
       
  0.987
eIF-2beta
Eukaryotic initiation factor 2beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region (312 aa)
     
 
  0.984
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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