STRINGSTRING
mei-38 protein (fruit fly) - STRING interaction network
"mei-38" - Meiotic 38 in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mei-38Meiotic 38 (325 aa)    
Predicted Functional Partners:
msd1
Mitotic spindle density 1 (138 aa)
     
        0.688
cid
Centromere identifier; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (225 aa)
     
   
  0.662
borr
Borealin-related; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of embryonic mitosis. The CPC complex has essential functions at the centromere for ensuring sister chromatid cohesion, recruitment of the CPC to kinetochores, and chromosome alignment and segregation. There is no function in meiotic histone phosphorylation or spindle formation (319 aa)
     
   
  0.650
spd-2
Spindle defective 2 (1146 aa)
     
   
  0.640
bora
Aurora borealis; Required for the activation of Aurora-A (aur) at the onset of mitosis (539 aa)
     
   
  0.634
Incenp
Inner centromere protein (755 aa)
     
   
  0.612
CG11164
Uncharacterized protein, isoform A (340 aa)
     
        0.562
CG13690
Ribonuclease H activity; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes (By similarity) (347 aa)
     
        0.553
ncd
Non-claret disjunctional; NCD is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The NCD motor activity is directed toward the microtubule’s minus end (700 aa)
     
   
  0.538
ial
IplI-aurora-like kinase; Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 ’Ser-10’ phosphorylation. Phosphorylates mei-S332 within residues 124-126 and stabilizes its association with centromeres during meiosis (329 aa)
     
   
  0.535
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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