node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gdi | Rab27 | FBpp0311558 | FBpp0070280 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | 0.844 |
Gdi | Rab3-GEF | FBpp0311558 | FBpp0303427 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. | 0.640 |
Gdi | Rab5 | FBpp0311558 | FBpp0077473 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | 0.982 |
Gdi | Rab6 | FBpp0311558 | FBpp0312096 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...] | 0.993 |
Gdi | Rep | FBpp0311558 | FBpp0085658 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). | 0.533 |
Rab27 | Gdi | FBpp0070280 | FBpp0311558 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | 0.844 |
Rab27 | Rab3-GEF | FBpp0070280 | FBpp0303427 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. | 0.790 |
Rab27 | Rab5 | FBpp0070280 | FBpp0077473 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | 0.637 |
Rab27 | Rab6 | FBpp0070280 | FBpp0312096 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...] | 0.687 |
Rab27 | Rep | FBpp0070280 | FBpp0085658 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). | 0.858 |
Rab27 | Rph | FBpp0070280 | FBpp0071431 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Rabphilin, isoform A; Rab GTPase binding; calcium-dependent phospholipid binding. It is involved in the biological process described with: synaptic vesicle exocytosis; exocytosis; intracellular protein transport; neurotransmitter secretion; vesicle-mediated transport. | 0.776 |
Rab27 | TSG101 | FBpp0070280 | FBpp0075088 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles. | 0.622 |
Rab27 | btsz | FBpp0070280 | FBpp0306407 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Bitesize, isoform I; Bitesize (btsz) encodes a membrane-trafficking protein that contributes to actin cytoskeleton organization. It is involved in the establishment of planar cell polarity, apical junction assembly and the morphogenesis of salivary glands and the tracheal system. | 0.846 |
Rab27 | didum | FBpp0070280 | FBpp0088684 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Dilute class unconventional myosin (didum) encodes a class V unconventional myosin that binds actin and hydrolyzes ATP. It functions in mRNA localization in the oocyte, spermatid individualization during spermatogenesis, transport of pigment granules in photoreceptors and mitochondrial transport in neuronal cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.663 |
Rab27 | stac | FBpp0070280 | FBpp0292144 | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | Protein unc-13 homolog 4B; Essential for tracheal development in embryos. Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis). Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs). Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membra [...] | 0.622 |
Rab3-GEF | Gdi | FBpp0303427 | FBpp0311558 | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | 0.640 |
Rab3-GEF | Rab27 | FBpp0303427 | FBpp0070280 | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. | EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion. | 0.790 |
Rab3-GEF | Rep | FBpp0303427 | FBpp0085658 | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. | Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). | 0.416 |
Rab3-GEF | Rph | FBpp0303427 | FBpp0071431 | MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms. | Rabphilin, isoform A; Rab GTPase binding; calcium-dependent phospholipid binding. It is involved in the biological process described with: synaptic vesicle exocytosis; exocytosis; intracellular protein transport; neurotransmitter secretion; vesicle-mediated transport. | 0.419 |
Rab5 | Gdi | FBpp0077473 | FBpp0311558 | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | 0.982 |