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STRINGSTRING
Rab27 protein (fruit fly) - STRING interaction network
"Rab27" - Protein binding in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
Rab27Protein binding; GTPase activity; GTP binding. It is involved in the biological process described with- sleep; vesicle-mediated transport; Rab protein signal transduction; protein transport (236 aa)    
Predicted Functional Partners:
Rab3-GEF
MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase- mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms (2130 aa)
         
  0.981
Rph
Rabphilin, isoform A; Protein transporter activity; calcium-dependent phospholipid binding; Rab GTPase binding. It is involved in the biological process described with- vesicle-mediated transport; synaptic vesicle endocytosis; intracellular protein transport; neurotransmitter secretion; synaptic vesicle exocytosis (638 aa)
     
 
  0.976
Rep
Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity) (511 aa)
     
  0.958
Gdi
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP (443 aa)
     
  0.949
betaggt-II
Beta subunit of type II geranylgeranyl transferase; CAAX-protein geranylgeranyltransferase activity; Rab geranylgeranyltransferase activity. It is involved in the biological process described with- protein geranylgeranylation (347 aa)
       
  0.940
Rab23
RH23273p; GTPase activity; GTP binding. It is involved in the biological process described with- vesicle-mediated transport; Rab protein signal transduction; protein transport; morphogenesis of a polarized epithelium (268 aa)
   
 
0.928
Rab30
Rab30, isoform A; Protein binding; GTPase activity; GTP binding. It is involved in the biological process described with- vesicle-mediated transport; Rab protein signal transduction; protein transport; head involution; dorsal closure; imaginal disc fusion, thorax closure; germ-band shortening (223 aa)
   
   
0.926
Rab21
Rab21, isoform C; Protein binding; GTPase activity; phosphatidylinositol 3-kinase catalytic subunit binding; GTP binding. It is involved in the biological process described with- vesicle-mediated transport; Rab protein signal transduction; cortical actin cytoskeleton organization; protein transport (222 aa)
   
   
0.924
Rab5
Rab5, isoform A; Rab5 is a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering Rab5 activity affects many receptor-mediated signaling pathways as well as epithelial polarity (219 aa)
   
   
0.924
Rab35
Rab35, isoform A; GTPase activity; GTP binding. It is involved in the biological process described with- phagocytosis; mitotic cytokinesis; vesicle-mediated transport; Rab protein signal transduction; protein transport; cytokinesis (201 aa)
   
   
0.923
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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