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Rbcn-3B protein (fruit fly) - STRING interaction network
"Rbcn-3B" - Rabconnectin-3B, isoform A in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rbcn-3BRabconnectin-3B, isoform A; Rabconnectin-3B (Rbcn-3B) is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. Rbcn-3B is involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells (1525 aa)    
Predicted Functional Partners:
Csp
DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) is a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. Csp protein substrates include SNARE proteins and shi, which mediate synaptic vesicle exo- and endocytosis respectively (249 aa)
     
   
  0.873
Rbcn-3A
Rabconnectin-3A (Rbcn-3A) is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. Rbcn-3A is involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells (3426 aa)
     
 
  0.821
Rab3-GAP
Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity) (1341 aa)
     
   
  0.794
Lnk
Lnk, isoform A; Signal transducer activity. It is involved in the biological process described with- female mating behavior; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of insulin receptor signaling pathway; regulation of growth; TORC1 signaling; signal transduction (723 aa)
           
  0.677
Crag
Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein is a guanine exchange factor for Rab10 and Rab11. It is involved in the exclusive secretion of basement membrane proteins on the basal side of cells (1671 aa)
     
   
  0.608
Fis1
Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Functions downstream of Pink1 and upstream of Drp1 to regulate mitochondrial fission (154 aa)
       
 
  0.593
Rab3-GEF
MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase- mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms (2130 aa)
     
   
  0.589
CG10903
Uncharacterized protein, isoform A; S-adenosylmethionine-dependent methyltransferase activity. It is involved in the biological process described with- neurogenesis; metabolic process (276 aa)
       
 
  0.584
CG32758
Uncharacterized protein, isoform A; Phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with- endosomal transport; intracellular protein transport; signal transduction (531 aa)
     
   
  0.567
tst
Twister, isoform A; ATP binding; nucleic acid binding; helicase activity. It is involved in the biological process described with- regulation of alternative mRNA splicing, via spliceosome (1197 aa)
     
 
  0.563
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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