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CG4313 protein (fruit fly) - STRING interaction network
CG4313, isoform D in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CG4313CG4313, isoform D (572 aa)    
Predicted Functional Partners:
Gbeta13F
GTPase activity; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
     
    0.933
Galphas
GTPase activity; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase (By similarity) (385 aa)
       
    0.917
moody
Moody; Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the form [...] (670 aa)
         
0.908
Tre1
Trapped in endoderm 1; Essential for the first active step of germ cell migration- transepithelial migration of germ cells through the posterior midgut (PMG) epithelium (392 aa)
         
0.906
Octbeta3R
Octbeta3R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed-25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed-25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed-25605909) (1256 aa)
     
 
 
0.902
oa2
Octopamine receptor 2; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed-15816867, PubMed-22553037). Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed-22553037). Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed-22553037) (508 aa)
         
 
0.900
Oamb
Octopamine receptor activity; Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates (PubMed-9570796, PubMed-15816867). Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding (PubMed-9570796, PubMed-15816867). Required for ovulation (PubMed-14623240, PubMed-19262750). Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation (PubMed-26473732). Ligand binding probably also leads to activatio [...] (751 aa)
         
 
0.900
Octbeta2R
Octbeta2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed-15998303, PubMed-21186359). Essential for ovulation and fertilization (PubMed-25099506, PubMed-25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed-25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed-21186359 [...] (630 aa)
         
 
0.900
D2R
Dopamine 2-like receptor; Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (606 aa)
         
 
0.900
5-HT7
Serotonin receptor 7; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling activates adenylate cyclase activity (564 aa)
         
 
0.900
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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