STRINGSTRING
Sik2 protein (fruit fly) - STRING interaction network
"Sik2" - Salt-inducible kinase 2 in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sik2Salt-inducible kinase 2 (1398 aa)    
Predicted Functional Partners:
SNF4Agamma
AMP-activated protein kinase activity (1400 aa)
     
  0.950
alc
Alicorn (341 aa)
     
  0.949
ACC
Acetyl-CoA carboxylase (2571 aa)
     
  0.928
lkb1
Lkb1 (567 aa)
     
0.828
ras
Raspberry; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (537 aa)
     
  0.758
CG17698
Calmodulin-dependent protein kinase activity (694 aa)
     
 
0.745
HDAC4
HDAC4 (1269 aa)
     
 
  0.714
HDAC6
HDAC6 (1179 aa)
     
 
  0.705
SR3-9
14-3-3epsilon; Positively regulates Ras-mediated pathways. Acts downstream or parallel to Raf, but upstream of nuclear factors in Ras signaling. Three mutants have been isolated, that suppress the rough eye phenotype caused by mutated Ras1 (sev-Ras1 v12). Inhibits yki activity by restricting its nuclear localization (262 aa)
     
  0.661
CG4629
Protein serine/threonine kinase activity (570 aa)
     
0.660
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: low (12%) [HD]