STRINGSTRING
pn protein (fruit fly) - STRING interaction network
"pn" - Prune in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pnPrune (405 aa)    
Predicted Functional Partners:
Mesh1
Metazoan SpoT homolog-1; ppGpp hydrolyzing enzyme involved in starvation response (179 aa)
       
  0.926
wapl
Wings apart-like; Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation (1741 aa)
           
  0.580
Top2
Topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands (PubMed-6308011, PubMed-2547764, PubMed-1328202, PubMed-8383533, PubMed-10786800, PubMed-8978614). Topoisomerase II makes double-strand breaks (PubMed-6308011, PubMed-2547764, PubMed-1328202, PubMed-8383533, PubMed-10786800, PubMed-9545289). Essential during mitosis and meiosis for proper segregation of daughter chromosomes (PubMed-10751154, PubMed-14600258, PubMed-18752348, PubMed-25340780). During meiosis, it disrupts heterochromatic connections between achiasmate and c [...] (1447 aa)
         
  0.506
CG11593
Uncharacterized protein, isoform B (484 aa)
 
       
  0.458
ras
Raspberry; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (537 aa)
   
   
  0.432
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: low (18%) [HD]