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Ilp6 protein (fruit fly) - STRING interaction network
"Ilp6" - Probable insulin-like peptide 6 in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Ilp6Probable insulin-like peptide 6; Hormone activity; insulin receptor binding. It is involved in the biological process described with- insulin receptor signaling pathway; positive regulation of multicellular organism growth (107 aa)    
Predicted Functional Partners:
Ilp5
Probable insulin-like peptide 5; Hormone activity; insulin receptor binding. It is involved in the biological process described with- female mating behavior; insulin receptor signaling pathway; sleep; locomotory behavior (107 aa)
         
  0.991
Ilp3
Probable insulin-like peptide 3; Hormone activity; insulin receptor binding. It is involved in the biological process described with- female mating behavior; insulin receptor signaling pathway; sleep; locomotor rhythm (120 aa)
         
  0.990
Ilp1
Probable insulin-like peptide 1; Hormone activity; insulin receptor binding. It is involved in the biological process described with- insulin receptor signaling pathway (154 aa)
         
  0.984
Ilp7
Probable insulin-like peptide 7; Hormone activity; insulin receptor binding. It is involved in the biological process described with- insulin receptor signaling pathway (159 aa)
         
  0.984
Ilp4
Probable insulin-like peptide 4; Hormone activity; insulin receptor binding. It is involved in the biological process described with- insulin receptor signaling pathway; larval feeding behavior (134 aa)
         
  0.984
InR
Insulin-like receptor; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell- autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination (2144 aa)
         
  0.982
Ilp2
Probable insulin-like peptide 2; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway (137 aa)
         
  0.973
chico
Insulin receptor substrate 1; Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth fac [...] (968 aa)
         
  0.954
Akt1
RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa)
         
  0.940
Pi3K92E
Phosphoinositide 3-kinase, Dp110; SH3 domain binding; 1-phosphatidylinositol-4-phosphate 3-kinase activity; phosphatidylinositol 3-kinase activity; lipid kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; Belongs to the PI3/PI4-kinase family (1088 aa)
         
  0.931
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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