STRINGSTRING
wapl protein (fruit fly) - STRING interaction network
"wapl" - Wings apart-like in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
waplWings apart-like; Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation (1741 aa)    
Predicted Functional Partners:
Cap
ATP binding (1200 aa)
     
  0.991
pds5
CG17509 gene product from transcript CG17509-RB (1218 aa)
     
  0.989
vtd
Verthandi (715 aa)
     
  0.987
SMC1
SMC1 (1238 aa)
     
  0.984
SA
Stromalin (1127 aa)
     
  0.980
Nipped-B
Nipped-B; Plays a structural role in chromatin. Involved in sister chromatid cohesion, probably via an interaction with the cohesin complex. Participates in the transcriptional activation mediated by remote enhancers on genes such as cut and Ubx, possibly by alleviating the cohesin-mediated blocking of enhancer-promoter communication (2077 aa)
     
 
  0.964
eco
Eco; Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase (1052 aa)
     
 
  0.959
CG4203
Protein binding; Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity) (632 aa)
     
 
  0.942
SA-2
Stromalin-2 (973 aa)
     
  0.942
CycB
Cyclin B; Essential for the control of the cell cycle at the G2/M (mitosis) transition (530 aa)
     
 
  0.927
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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