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CG16903 protein (fruit fly) - STRING interaction network
"CG16903" - LD24704p in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
CG16903LD24704p; Protein kinase binding; cyclin-dependent protein serine/threonine kinase regulator activity. It is involved in the biological process described with- RNA processing; regulation of transcription, DNA-templated; neurogenesis; regulation of cyclin-dependent protein serine/threonine kinase activity (560 aa)    
Predicted Functional Partners:
Cdk4
ATP binding; cyclin-dependent protein serine/threonine kinase activity; protein serine/threonine kinase activity; cyclin binding. It is involved in the biological process described with- regulation of cell growth; protein phosphorylation; cell proliferation; mitochondrion organization; blastoderm segmentation; JAK-STAT cascade; regulation of cell cycle; mitotic cell cycle; cell growth; open tracheal system development (317 aa)
     
  0.854
CG40191
Uncharacterized protein, isoform B; Protein kinase binding. It is involved in the biological process described with- regulation of cyclin-dependent protein serine/threonine kinase activity (396 aa)
     
   
  0.847
CycH
Cyclin H homolog; RNA polymerase II carboxy-terminal domain kinase activity; protein kinase binding; core RNA polymerase binding transcription factor activity; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity. It is involved in the biological process described with- transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter (324 aa)
     
 
  0.842
Cdk12
Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity- hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation (1157 aa)
     
  0.828
BCAS2
LD24242p; It is involved in the biological process described with- mRNA splicing, via spliceosome; mRNA processing (278 aa)
     
 
  0.825
Cdk8
Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C-terminal domain) of the [...] (454 aa)
     
 
  0.804
Mcm2
DNA replication licensing factor Mcm2; Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (887 aa)
     
 
  0.774
Cdk7
Cyclin-dependent kinase 7 (Cdk) is a serine/threonine protein kinase whose activity depends on the regulatory CycH and Mat1 subunits. This trimeric Cdk complex activates other Cdks by phosphorylation in their T-loop and is called Cdk activating kinase (CAK). CAK can also be part of TFIIH, where Cdk7 phosphorylates different transcription substrates (e.g. CTD of Pol II) (353 aa)
     
 
  0.762
CG6800
CG6800; ATP binding; cyclin-dependent protein serine/threonine kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with- protein phosphorylation (302 aa)
     
 
  0.750
cdc2rk
Cdc2-related kinase; ATP binding; cyclin-dependent protein serine/threonine kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with- protein phosphorylation; mRNA splicing, via spliceosome (387 aa)
     
 
  0.699
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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