STRINGSTRING
mit(1)15 protein (fruit fly) - STRING interaction network
"mit(1)15" - Mitotic 15 in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mit(1)15Mitotic 15; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed-15886105, PubMed-17576797). Required for the assembly of the dynein- dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores (PubMed-15886105, PubMed-17576797). During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1 (PubMed-22685323). Required for maintenance of Golgi stack number and morphology, and acroblast assembly (PubMed-22685323). Its function related to the spindle assemb [...] (721 aa)    
Predicted Functional Partners:
zwilch
Zwilch; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed-15886105, PubMed-17576797). Required for the assembly of the dynein- dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores (PubMed-15886105, PubMed-17576797). Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex (PubMed-22685323). Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane comp [...] (641 aa)
     
  0.996
CG8605
RINT1 ortholog; During cytokinesis in male meiotic cells, required for completion of cleavage furrow ingression possibly in conjunction with Zw10. Required for maintenance of Golgi stack number and morphology. Essential for acroblast assembly (724 aa)
     
  0.989
rod
Rough deal (2089 aa)
     
  0.989
BubR1
Bub1-related kinase (1460 aa)
     
  0.980
Syx18
Syntaxin 18 (395 aa)
     
  0.975
cmet
CENP-meta (2189 aa)
     
 
  0.974
Use1
Use1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion (250 aa)
     
    0.957
ald
Altered disjunction (672 aa)
     
 
  0.945
Spc105R
Spc105-related (1960 aa)
     
 
  0.937
polo
Polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (576 aa)
     
 
  0.933
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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