STRINGSTRING
Klp3A protein (fruit fly) - STRING interaction network
"Klp3A" - Microtubule binding in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Klp3AMicrotubule binding (1212 aa)    
Predicted Functional Partners:
Klp61F
Motor activity; Important role in mitotic dividing cells (PubMed-8227131). Microtubule motor required for spindle body separation (PubMed-8918872). Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function (PubMed-8918872, PubMed-8589456, PubMed-19062285). Forms cross-links between microtubules within interpolar microtubule bundles (PubMed-9885249, PubMed-19158379). Contributes to the length of the metaphase spindle, maintains the prometaphase spi [...] (1066 aa)
     
 
0.977
Klp67A
Motor activity (814 aa)
     
0.973
tubA84B
alpha-Tubulin at 84B; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (450 aa)
     
  0.965
Klp10A
Klp10A; Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux" (PubMed-14681690, PubMed-20946984, PubMed-24100293). Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara- expressing endosomes to the central spindle which is symmetrically arranged in early [...] (805 aa)
     
0.955
ncd
Non-claret disjunctional; NCD is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The NCD motor activity is directed toward the microtubule’s minus end (700 aa)
     
 
0.954
pav
Pavarotti (887 aa)
     
 
0.952
feo
Fascetto (671 aa)
     
 
  0.937
Khc
Kinesin heavy chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (975 aa)
     
0.928
Kap3
Protein binding (1038 aa)
     
  0.923
Gl
Glued; Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles (1265 aa)
     
 
  0.923
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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